Alteration in memory and electroencephalogram waves with sub-acute noise stress in albino rats and safeguarded by Scoparia dulcis. Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice. Social deprivationstress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice. Mod Pathol.1998 11:155–68.īerry A, Bellisario V, Capoccia S, Tirassa P, Calza A, Alleva E, Cirulli F. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Neuroscience 2012 223: 238-45Īllred DC, Harvey JM, Berardo M, et al. Bax and B-cell-lymphoma 2 mediate proapoptotic signaling following chronic isolation stress in rat brain. Protective effect of water extracy of propolis on dopaminergic neurons, Brain derived neurotrophic factor and stress oxidative factors in the rat model of parkinson’s disease. Safari M, Sameni HR, Badban L, Bandegi AR, Vafaei AA, Pour AR, Ghahari L. Propolis inhibited Bax expression and increased neuronal count of hippocampal area CA1 in rats receiving sodium nitrite. Kuswati, Handayani ES, Nugraha ZS, Rahmanti FA. Evidence on the Health Benefifits of Supplemental Propolis. Stress effect on BDNF expression: effect of age, sex and form of stress. Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice. 2013 2:25-32.Īlboni S, Tascedda F, Corsini D, Benatti C, Caggia F, Capone G, et al. Anti stress of centella asiatica leaf extract on hippocampal CA3 neurons - a quatitative study. Propolis increases neuronal count in hippocampal area CA1 and prefrontal cortex in stressed rats. Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders. Brain-derived neurotrophic factor and its clinical Implications. Propolis dose of 100 mg/kgBW/day has increased BDNF expression.īathina S, Das UN. The highest BDNF expression was in the P3 group and the lowest in group K.Ĭonclusion: There is an effect of propolis on BDNF expression in the hippocampus of the stress-induced rat. Results: There is a significant difference in BDNF expression in the CA1 area of the hippocampus in all groups (p=0.000). Observations were made with a light microscope with 1000x magnification in the CA1 area of the hippocampus. Immunohistochemical staining using anti-BDNF antibodies was performed to make histological slides. In the end, the rats were terminated and brain tissue was collected. Oral propolis administration used oral gavage. Social isolation stress was carried out by putting one rat in one cage. Rats were randomly divided into five groups: group N, did not receive any treatment group K, received stress treatment groups P1, P2, and P3, received stress treatment and followed by administered propolis at doses of 100, 150, and 200 mg/kg/day. The subjects were 25 male Spraque-Dawley rats (Rattus norvegicus), four months old, weighing 200-300 grams. Methods: Experimental study using posttest only control group design. Objective: This study aimed to examine the effect of propolis on BDNF expression in the hippocampus of stress-induced rats. Propolis contains chrysin which has antioxidant and neuroprotectant effects. Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin secreted by dendrite, which plays a role in differentiation, maturation, neuroplasticity, learning, and memory, which the expression decreases under stress conditions.